Leading, global pharmaceutical company is generating new insights and uncovering new research directions with DISQOVER
Industry Pharmaceutical
Number of employees +75,000
Location Europe
OUR CUSTOMER
Our customer is a leading, global pharmaceutical company that is committed to delivering innovative medicines to improve patient outcomes. They are heavily focused on oncology.
Use cases
Clinical Trial Design
Translational Medicine
Scientific Intelligence
Real-world evidence
The challenge
Our customer commissioned an internal, cross-disciplinary project in order to better understand biological mechanisms of immuno-oncology (I-O) resistance in cancer patients and to bolster biomarker identification. In contrast to previous approaches for studying I-O resistance, greater quantities of data and multiple clinical trial datasets needed to be harmonized and combined.
This presented an initial challenge due to the varying quality of the datasets: some sets were generated by internal pipelines, some by vendors, some already pre-formatted by ingestion scripts, and others were generated years ago by now obsolete pipelines.
The outcome
Using ONTOFORCE’s DISQOVER, our customer was able to gather all sample information and connect the data within the DISQOVER knowledge graph. They were also able to combine their own ontologies with public ontologies. This ensured metadata followed controlled vocabularies and FAIR principles, and the provenance of the data source was recorded in DISQOVER to maintain full traceability.
As a result, curated datasets are now available for several studies and modalities. These datasets are being used to generate several new insights in I-O through different approaches (novel biomarker detection, cross-studies differential gene expression).
Benefits
DISQOVER streamlines data curation
Using DISQOVER has reduced the time spent on curating and harmonizing disparate datasets.
DISQOVER reveals data relationships
DISQOVER is helping our customer to identify trends and relationships between different datasets, when previously they could only look at single project data in isolation.
DISQOVER boosts biomarker research
Enhancing novel biomarker identification and widening the understanding of biological resistance in immuno-oncology.
For this customer, their customized DISQOVER platform operates as an interactive dashboard, providing search and browsing capabilities to enable widespread data access and analysis tools in order to unlock a deeper understanding of immuno-oncology and facilitate new research directions.
Case Study
